栾明明  博士，硕士生导师

联系方式

邮箱：luanmm@qlu.edu.cn

办公室：食工楼C517

学习及工作经历

2018.12-至今    齐鲁工业大学 化学与化工学院  

2013.09-2018.12  山东师范大学  化学化工与材料科学学院  分析化学  博士

2008.09-2013.07  烟台大学文经学院  食品与生物工程系  讲师

2006.04-2008.07  常熟理工学院  化学与材料工程系  讲师

2003.09-2006.04  浙江大学  化学系  分析化学  硕士

1999.09-2003.07  烟台大学  化学生物理工学院  应用化学  学士

研究领域

1. 纳米荧光探针的设计构建及其在生物成像中的应用

2. 早期肿瘤标志物和抗癌药物疗效的可视化诊断、评估

3. 纳米酶的设计合成及其在生物医学的应用

主持和参与科研项目

1. 国家自然科学基金青年项目，高灵敏纳米荧光探针用于动态可视化监测microRNA调控癌细胞凋亡及其在药效评估的应用（项目号21904074, 2020.01.01-2022.12.31, 25万元, 结题，主持）

2. 国家自然科学基金面上项目，表面与针尖增强拉曼光谱的高精度量子化学计算与人工智能预测 （项目号22073053, 2021.01.01-2024.12.31, 63万元, 在研，参与）

3. 国家自然科学基金面上项目，纳米载体材料对细胞的安全性评估：比率荧光纳米探针实时检测成像活性氧水平的变化, （项目号21775094,  2018.01.01-2021.12.31, 64万元, 结题，参与）

4. 国家自然科学基金重点项目，亚细胞结构水平上活性小分子协同调控细胞功能的荧光成像研究（项目号21535004，2016.01.01-2020.12.01，300.00万元，结题，参与）

5. 国家重大科研仪器研制项目，单分子检测系统及其关键技术研究（项目号21527811，2016.01.01-2020.12.01，548.00万元，结题，参与）

发表论文

15. Mingyao Ren, Zhe Chen, Chuandong Ge, Wei Hu, Jing Xu, Limin Yang, Mingming Luan^* and Nianxing Wang^* Visualizing MiRNA Regulation of Apoptosis for Investigating the Feasibility of MiRNA-Targeted Therapy Using a Fluorescent Nanoprobe. Pharmaceutics.2022, 14, 1349. 2022-06-25

14. Mingyao Ren^†, Zhe Chen^†, Chuandong Ge, Wei Hu, Nianxing Wang, Limin Yang, Mingming Luan^* and Jing Xu^* Simultaneous Visualization of MiRNA-221 and Caspase-3 in Cancer Cells for Investigating the Feasibility of MiRNA-Targeted Therapy with a Dual-color Fluorescent Nanosensor. Biosensors.2022, 12, 444.   2022-06-23

13. Bo Liu, Ping Zhou, Kaiye Wang, Shaohua Gong, Mingming Luan, Na Li*, and Bo Tang*. Avoiding False Positive Signals: A Powerful and Reliable Au−Se Dual-Color Probe. ACS Sens.2021, 6(5), 1949–1955.

12. Ping Zhou,^a Bo Liu,^aMingming Luan,^b Na Li ^*a and Bo Tang ^*a   A fluorescence nanoprobe for detecting the effect of different oxygen and nutrient conditions on breast cancer cells migration and invasion. Biomater. Sci., 2021, 9(12), 4428-4432.

11. Chunhong Gao ^a,#, Zhen Zhang ^a,#, Shu Xing ^a, Mingming Luan^a, Tingting Gai ^a, Zhaosheng Hou ^b, Tianduo Li ^a, Jing Xu ^a,* Self-assembled gelatin monolayer with coordinating regulation the composition, charge and wettability on the titanium surface

Surfaces and Interfaces， Volume 25, August 2021, 101281

10. Xiaonan Gao ¹, Jia Li ¹, Mingming Luan, Yanhua Li, Wei Pan, Na Li ^*, Bo Tang ^**. Real-time in situ monitoring of signal molecules’ evolution in apoptotic pathway via Au–Se bond constructed nanoprobe. Biosens. Bioelectron. 2020, 147, 111755.

9. Mingming Luan, Wei Pan, Na Li*, and Bo Tang*, Real-Time in Situ Investigation of Upstream and Downstream Relationship between uPA and MMP-9 in MCF-7 and PANC-1 cells via Au-Se-Bond-Based Nanoprobe. Chem. Commun., 2019, 55, 5817-5820.

8. Mingming Luan, Jinjie Chang, Wei Pan, Yuanyuan Chen, Na Li* and Bo Tang*, Simultaneous Fluorescence Visualization of Epithelial–Mesenchymal Transition and Apoptosis Processes in Tumor Cells for Evaluating the Impact of Epithelial–Mesenchymal Transition on Drug Efficacy. Anal. Chem., 2018, 90, 10951-10957.

7. Mingming Luan, Longhai Yu, Yanhua Li, Wei Pan, Xiaonan Gao, Xiuyan Wan, Na Li* and Bo Tang*, Visualizing Breast Cancer Cell Proliferation and Invasion for Assessing Drug Efficacy with a Fluorescent Nanoprobe. Anal. Chem., 2017, 89, 10601-10607.

6. Mingming Luan, Na Li, Wei Pan, Limin Yang, Zhengze Yu and Bo Tang*, Simultaneous detection of multiple targets involved in the PI3K/AKT pathway for investigating cellular migration and invasion with a multicolor fluorescent nanoprobe. Chem. Commun., 2017, 53, 356-359.ESI高被引

5.栾明明，邬建敏，叶庆富, 多次循环离子交换色谱纯化Cry1Ab 蛋白及其肽质量谱图的分析. 浙江大学学报, 2007, 529-532.

4. Jianmin Wu, Mingming Luan, Jiayin Zhao. Trypsin immobilization by direct adsorption on metal ion chelated macroporous chitosan-silica gel beads. International Journal of Biological Macromolecules. 2006, 39, 185–191.

3. 栾明明，邬建敏，溶胶凝胶膜包埋的胰蛋白酶用于高通量蛋白质肽谱分析.分析化学, 2006, 34, 1707-1710.

2. Mingming Luan, Fengna Xi, Jianmin Wu. New metal chelate affinity adsorbent for trypsin immobilization. Abstract Book of International Symposium on Biocatalysis and Bioprocess Engineering. 2005, 126-127.

1. Fengna Xi, Jianmin Wu, Mingming Luan. Silica-supported macroporous chitosanbead for affinity purification of trypsin inhibitor. Chinese Chemical Letters. 2005, 16.

奖励和荣誉：

山东省高等学校科学技术奖一等奖，第四位，2019.12.23

主讲课程：

工程化学、无机化学、分析化学、仪器分析、环境监测等课程