王晓
发布时间: 2017-03-21   浏览次数: 277      



博士生导师,二级研究员;山东省有突出贡献中青年专家

山东省科学院分析测试中心主任

山东省中药质量控制技术重点实验室主任

电话: 0531-260530413031748019Emailwangx@sdas.org



教育背景:

19919-19957山东农业大学本科

19959-19987山东农业大学硕士研究生

20029-20053山东农业大学博士研究生

工作经历

19987-200112山东省科学院分析测试中心研究实习员

20021-200512山东省科学院分析测试中心助理研究员

20029-20053山东农业大学博士研究生

20061-20097山东省科学院分析测试中心研究员

20098-20157山东省科学院分析测试中心中心副主任,研究员

20154-至今山东省科学院分析测试中心主任,研究员

20097-20131中国中医科学院博士后

专业:天然产物化学

研究方向:天然活性成分提取分离纯化技术研究

天然活性成分分析技术研究

天然植物资源高值化开发利用

中药质量控制

学术成果:

主持承担的项目:

近几年来主持承担国家自然科学基金、国家十二五科技支撑计划、国家863计划子课题等国家、省市各级科研项目30余项。部分科研项目如下:

1.国家自然科学基金面上项目“基于双重胁迫假说的金银花干燥过程的褐变机制研究”(2015-2018

2.国家自然科学基金“基于可逆络合反应的高速逆流色谱体系及分离机理研究2009-2011

3.国家自然科学基金主任基金“辣椒干制过程中红编变机制及调控2011

4.国家863计划子课题“药食同源重要功能因子提取、分离及规模化生物合成关键技术研究”2015-2016

5.国家十二五科技支撑计划“栝楼规范化种植基地及其SOP优化升级研究”(2012-2015

6.国家质检行业公益性科研专项基于过程控制的农产品购销服务重要技术标准研究及示范(2013-2014)

7.国家重大新药创制项目中药与天然药物活性物质高效分离纯化单元技术平台2012-2014

8.国家质检行业公益性科研专项重要农产品中不同类型标准样品研究(2011-2012)

9.山东省自主创新重大科研专项“金银花资源高值产品开发”(2013-2015

10.山东省重点研发计划“基于功效的道地金银花药材质量评价体系研究”(2015-2017

  

发表论文:

以第一作者或通讯作者在Journal of Chromatography A Journal of Chromatography BFood ChemistryJournal of Separation SciencePhytochemical Analysis等国内外重要刊物发表论文200余篇, SCI收录80余篇,SCI他引1000余次。编著、参编著作5部。

1.Heng Zhu, Daijie Wang, Lei Wen ,Jinqian Yu ,Yanling Geng  ,HengqiangZhao, Xiao Wang*Preparative separation of quaternary ammonium alkaloids from Caulis Mahoniae by conventional and pH-zone-refining counter-current chromatography. RSC Advances,2016, 6, 83343–83349

2.Minmin Zhang, Hengqiang Zhao, Zhiguo Zhao, Huijiao Yan, Ruimin Lv, Li Cui, Jinpeng Yuan, Daijie Wang, Yanling Geng, Daicheng Liu, Xiao Wang*.Rapid screening, identification, and purification of neuraminidase inhibitors from Lithospermum erythrorhizon Sieb.et Zucc. by ultrafiltration with HPLC–ESI-TOF-MS combined with semipreparative HPLC. Journal of Separation Science,2016,6,39(11):2097-2104

3.Hengqiang Zhao, Siduo Zhou, Minmin Zhang, Jinhong Feng, Shanshan Wang, Daijie Wang, Yanling Geng, Xiao Wang*.An in vitro AChE inhibition assay combined with UF-HPLC- ESI- Q-TOF/MS approach for screening and characterizing of AChE inhibitors from roots of Coptis chinensis Franch, Journal of Pharmaceutical and Biomedical Analysis,120 (2016) 235–240

4.Huaizhi Li, Yan Cheng, Hongjing Dong, Xiao Wang*, Jia Li, Qianshan Gao Preparation of salvianolic acid A by the degradation reaction of salvianolic acid B in subcritical water integrated with pH-zone-refining counter-current chromatography, Journal of Chromatography A,2016, 1468, 42-48

5.Wenhua Ji, Mingming Zhang, Wei Liu, Xingmin Wang ,Wenjuan Duan, Hongkai Xie and Xiao Wang*,Development of hydrophilic magnetic molecularly imprinted polymers by directly coating onto Fe3O4 with a water-miscible functional monomer and application in a solid-phase extraction procedure for iridoid glycosides, RSC Advances,2016, 6, 50487–50496

6.Wenhua Ji,Mingming Zhang,Qianshan Gao,Li Cui,Lizong Chen,and Xiao wang*, Preparation of hydrophilic molecularly imprinted polymers via bulk polymerization combined with hydrolysis of ester groups for selective recognition of iridoid glycosides, Analytical and Bioanalytical Chemistry,2016,408,5319-5328

7.Wenhua Ji, Hongkai Xie, Jie Zhou, Xiao Wang*, Xiuli Ma, Luqi Huang, Water-compatible molecularly imprinted polymers for selective solid phase extraction of dencichine from the aqueous extract of Panax notoginseng, Journal of Chromatography B, 2016, 1008, 225-233

8.Changlei Sun,Feng Liu,Jie Sun,Jia Li,Xiao Wang*, Optimisation and establishment of separation conditions of organicacids from Usnea longissima Ach. by pH-zone-refining counter –current chromatography:Discussion of the eluotropic sequence, Journal of Chromatography A, 2016,142796–101

9.Zhaoping Wang, Heng Zhu, Changlei Sun Xiao Wang*,  Jin-Qian Yu, Separation and purification of six compounds from the flowers of Cerasus yedoensis (Matsum.) by high-speed countercurrent chromatography in stepwise elution mode, Journal of Liquid Chromatography & Related Technologies,2016,39(11):532-537

10.Hongkai Xie, Wenhua Ji, Dahui Liu, Wei Liu, Daijie Wang, Ruimin Lv, Xiao Wang*,Surface molecularly imprinted polymers with dummy templates for the separation of dencichine from Panax notoginseng, RSC Advances, 2015, 5: 48885-48892

11.Qian Liu, Changlei Sun, Fansheng Meng, Wei Zhao, Dapeng Li & Xiao Wang*, Preparative Separation of Chelerythrine and Sanguinarine from Macleaya cordata by pH-Zone-Refining Counter-current Chromatography, Journal of Liquid Chromatography & Related Technologies,2015, 38(20): 1789-1793

12.Jin-Qian Yu,Wei Hang,Wen-Juan Duan ,Xiao Wang,* Dai-Jie Wang ,Xue-Mei Qin Anti-liver cancer constituents from the thorns of Gleditsia sinensis, Phytochemistry Letters, 2015.13,343-347

13.Xiuli Ma,Wenhua Ji,Lingxiao Chen,Xiao Wang*,Jianhua Liu,Xueyong Wang, Molecularly imprinted polymers with synthetic dummy templates for the preparation of capsaicin and dihydrocapsaicin from chili peppers, J. Sep. Sci,2015,38, 100–107

14.Wenhua Ji , Mingming Zhang , Daijie Wang , Xiao Wang  , Jianhua Liu a , Luqi Huang, Superhydrophilic molecularly imprinted polymers based on a water-soluble functional monomer for the recognition of gastrodin in water media. J. Chromatogr. A, 2015, 1425, 88-96

15.Wenhua Ji , Xiuli Ma,Jinghua Zhang , Hongkai Xie,Feng Xiao, Xiao Wang , Preparation of the high purity gingerols from ginger by dummy molecularly imprinted polymers, J. Chromatogr. A, 2015, 1387, 24 – 31

16.Changlei Sun, Wenjuan Duan, Xiao Wang*, Yanling Geng, Jia Li, Daijie Wang, Combinative Application of pH-Zone-Refining Counter-Current Chromatography and Preparative HPLC for the Separation of Alkaloids From Lycoris radiate, Journal of Liquid Chromatography & Related Technologies, 2015, 38: 1031–1036

17.Changlei Sun, Jia Li, Daijie Wang, Jinqian Yu, Xiao Wang*,  Luqi Huang, Preparative separation of alkaloids from Litsea cubeba using combined applications of pH-zone-refining and high-speed counter-current chromatography, RSC Advances, 2015, 5: 75831–75837

18.Xikai Shu, Wenjuan Duan , Feng Liu , Xingang Shi , Yanling Geng ,Xiao Wang *, Bingtian Yang, Preparative separation of polyphenols from the flowers of Paeonia lactiflora Pall. by high-speed counter-current chromatography, Journal of Chromatography B, 947–948 (2014) 62– 67

19.Wenhua Ji , Lingxiao Chen , Xiuli Ma , Xiao Wang *, Qianshan Gao ,Yanling Geng , Luqi Huang, Molecularly imprinted polymers with novel functional monomer for selective solid-phase extraction of gastrodin from the aqueous extract of Gastrodia elata, Journal of Chromatography A, 1342 (2014) 1–7

20.Feng Liu ,Xingjun Xi , Mei Wang ,Li Fan , Yanling Geng , Xiao Wang*, Isolation and purification of arctigenin from Fructus Arctii by enzymatic hydrolysis combined with high-speed counter-current chromatography, J. Sep. Sci, 2014, 37, 376–381

21.Feng Liu, Ronghua Zhu, Xiaojing Lin, Yanling Geng, Xiao Wang*, and Luqi Huang, Cloud Point Extraction and Pre-Concentration of Four Alkaloids in Nelumbo nucifera Leaves by Ultrahigh Pressure-Assisted Extraction, Separation Science and Technology, 49:981–987, 2014

22.Lingxiao Chen, Wenhua Ji , Wenjuan Duan, Xiao Wang* , Qianshan Gao, Yanling  Geng , Luqi Huang, Effectively designed molecularly imprinted polymers for selective extraction of glabridin from Glycyrrhiza glabra L. residues by screening the library of non-imprinted polymers, Journal of Chromatography B, 965 (2014) 1–6

23.Xueyong Wang  , Xikai Shu  , Xiao Wang*, Jinqian Yu  and Feng Jing ,Preparative Isolation of Seven Diterpenoid Alkaloids from Aconitum coreanum by pH-Zone-Refining Counter-Current Chromatography, Molecules, 2014, 19, 12619-12629

24.Wenhua Ji, , Xiuli Ma , Hongkai Xie , Lingxiao Chen , Xiao Wang* ,Hengqiang Zhao , Luqi Huang, Molecularly imprinted polymers with synthetic dummy template for simultaneously selective removal and enrichment of ginkgolic acids from Ginkgo biloba L. leaves extracts, Journal of Chromatography A, 1368 (2014) 44–51

25.Jin-Qian Yu,Wei Hang,Wen-Juan Duan,Xiao Wang*,Dai-Jie Wang, Xue-Mei Qin, Two new anti-HBV lignans from Herpetospermum caudigerum, Phytochemistry Letters, 10 (2014) 230–234

26.Wenjuan Duan · Aiying Bai ·Xiaojing Lin · Lei Fang · Xiao Wang*, Isolation and Purification of Highly Polar Antioxidants from Chirita longgangensis by Combination of Macroporous Resin and HSCCC, Chromatographia, (2014) 77:707–713

27.Na-na Liu , Wei Liu , Dai-jie Wang , Yi-bin Zhou, Xiao-jing Lin, Xiao Wang*, Sheng-bo Li, Purification and partial characterization of polyphenol oxidase from the flower buds of Lonicera japonica Thunb, Food Chemistry, 138 (2013) 478–483

28.Xiao Wang, Hongjing Dong, Bin Yang, Renyi Yan, and Luqi Huang, LARGE-SCALE SEPARATION OF STRYCHNINE AND BRUCINE FROM STRYCHNOS NUX-VOMICA L. BY pH-ZONE-REFINING COUNTER-CURRENT CHROMATOGRAPHY, Journal of Liquid Chromatography & Related Technologies, 36:648–657, 2013

29.Feng Liu, Di Wang , Wei Liu , Xiao Wang* , Aiying Bai , Luqi Huang, Ionic liquid-based ultrahigh pressure extraction of five tanshinones from Salvia miltiorrhiza Bunge, Separation and Purification Technology, 110 (2013) 86–92

30.Xikai Shu, Mei Wang and Daicheng Liu,Daijie Wang, Xiaojing Lin, Jianhua Liu, Xiao Wang *and Luqi Huang, PREPARATIVE SEPARATION OF POLYPHENOLS FROM ARTICHOKE BY POLYAMIDE COLUMN CHROMATOGRAPHY AND HIGH-SPEED COUNTER-CURRENT CHROMATOGRAPHY, Quim. Nova, Vol. 36, No. 6, 836-839, 2013

31.Xi-Kai Shu,Jia Li ,Feng Liu ,Xiao-Jing Lin,Xiao Wang*,Chun-Xia Song, Accelerated solvent extraction and pH-zone-refining counter-current chromatographic purification of yunaconitine and 8-deacetylyunaconitine from Aconitum vilmorinianum Kom, J. Sep. Sci, 2013, 36, 2680–2685

32.Lei Fang , Jie Zhou , YunLiang Lin, Xiao Wang *, Qinglei Sun, Jia-Lian Li , Luqi Huang, Large-scale separation of alkaloids from Gelsemium elegans by pH-zone-refining counter-current chromatography with a new solvent system screening method, Journal of Chromatography A, 1307 (2013) 80–85

33.YU SUN, SHUANGSHUANG XU, YANLING GENG,XIAO WANG *TIANYOU ZHANG, ISOLATION AND PURIFICATION OF LIGNANS FROM ISOLATION AND PURIFICATION OF LIGNANS FROM  Schisandra chinensis BY COMBINATION OF SILICA GEL COLUMN AND HIGH-SPEED COUNTER-CURRENT CHROMATOGRAPHY, Chemical Industry & Chemical Engineering Quarterly, 19 (3) 435−440 (2013)

34.Dahui Liu,Xikai Shu, Xiao Wang*, Lei Fang and Luqi Huang,Xingjun Xi and Zhenjia Zheng, PREPARATIVE SEPARATION OF C 19 -DITERPENOID ALKALOIDS FROM Aconitum carmichaelii Debx BY pH-ZONE-REFINING COUNTER-CURRENT CHROMATOGRAPHY, Quim. Nova, Vol. 36, No. 9, 1366-1369, 2013

专著:

1.pH-区带逆流色谱分离技术及应用, 化学工业出版社, 主编

2.高速逆流色谱技术,化学工业出版社,主编

3.Natural Products Extraction --Principle and Applications, The Royal Society of Chemistry, 参编

获得奖项:

获得国家科技进步二等奖、山东省科技进步一等奖等国家省部各级奖项17

1.国家科技进步二等奖“道地药材形成机理研究及应用,第五位,2011年度

2.山东省科技进步一等奖“天然产物分离制备关键技术及其国家标准样品研制”,第一位,2016年度

3.山东省科技进步二等奖“金银花良种选育与生产集成关键技术建立与推广应用,第二位,2013年度

4.山东省科技进步二等奖“山东省道地药材生产及质量控制技术体系建立与应用,第四位,2011年度

5.山东省科技进步二等奖“中药及其活性提取物的免疫调控关键技术与抗肿瘤作用研究,第四位,2011年度

6.山东省科技进步三等奖“木瓜种质库创建与新品种选育及产业化开发,第一位,2012年度

7.中国分析测试协会科学技术奖一等奖“天然产物活性成分印迹靶向分离技术及在标样研制中的应用”,第一位,2015年度

8.中国分析测试协会科学技术奖二等奖“基于逆流色谱的新型分离柱技术及天然活性成分分离制备方法研究”, 第二位,2012年度

9.中国分析测试协会科学技术奖二等奖“pH区带逆流色谱技术在离子型化合物分离制备中的应用”, 第一位,2012年度

授权专利:

1.天麻素分子印迹聚合物及其制备方法与应用,ZL201410084491.2,发明专利,第一位

2.一种非同步多分离柱高速逆流色谱仪, ZL201510032832.6,发明专利,第一位

3.一种光甘草定分子印迹聚合物及其制备方法和应用, ZL201310178727.4,发明专利,第一位

4.三分离柱高速逆流色谱仪,ZL201420237059.8,实用新型专利,第一位

5.高速逆流色谱仪,实用新型专利,第一位

6.种用于提取三七素的分子印迹聚合物的制备方法和应用,ZL201510128219.4,发明专利,第二位

7.一种姜酚假模板分子印迹聚合物及其从生姜中提取姜酚的方法,ZL201410589128.6,发明专利,第二位

8.一种良种金银花的育苗方法,ZL201310223321.3        ,发明专利,第二位

9.一种植物源烟水、制备方法以及烟水在促进丹参有效物质积累中的应用 ZL201310631035.0  ,发明专利,第二位

10.一种3D打印的逆流色谱分离柱及色谱仪,ZL2016 2 0185876.2,发明专利,第二位

11.金银花贮藏保鲜方法,中国知识产权局,发明专利,第二位

12.高纯度白鲜碱单体的制备方法,ZL201110454155.9,发明专利,第二位

  

学术兼职:

担任国际逆流色谱技术委员会委员、中药资源生态专业委员会副秘书长、国家标准样品委员会天然产物工作组副组长、山东省食品科学技术学会常务理事、中华中医药学会中药鉴定分会委员、中药标准化技术委员会委员、《中国中药杂志》编委、《山东科学》编委。
荣誉称号:

山东省有突出贡献中青年专家

第六届济南青年科技奖

第三届济南市青年科技明星称号。

指导研究生情况:

2006年起指导毕业硕士研究生50余人,升入澳门大学、中国中医科学院、中国农业大学、江南大学等高校院所攻读博士学位8人,多人次研究生获得国家奖学金。


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