王言才
发布时间: 2014-10-06   浏览次数: 1483      

 

王言才:药剂学博士,博士后,齐鲁工业大学,化学与制药工程学院,副教授。主要承担《药剂学》、《生物药剂学与药物动力学》等课程的授课和缓控释制剂设计及安全性评价等研究工作。

E-mailwangyancai1999@163.com   

Tel: 13869151991

 

受教育经历:

2008/09-2011/07,山东大学,药学院,药剂学,博士

2005/09-2008/07,江苏大学,药学院,药剂学,硕士

2001/09-2005/07,齐鲁工业大学,化学与制药工程学院,制药工程

 

 

研究工作经历:

2011/07-2013/06,齐鲁工业大学,化学与制药工程学院,讲师。

2012/02-2013/02,澳门大学,中华医药研究院

2013/07-今,齐鲁工业大学,化学与制药工程学院,副教授。

 

发表论文


[1]          Zhao, J., Y. Wang, Y. Ma, Y. Liu, B. Yan, and L. Wang, Smart nanocarrier based on PEGylated hyaluronic acid for deacetyl mycoepoxydience: High stability with enhanced bioavailability and efficiency. Carbohydr Polym, 2019. 203: 356-368.

[2]          Zhao, J., Y. Liu, L. Wang, Y. Zhou, J. Du, and Y. Wang, Functional and Modified Nanocrystals Technology for Target Drug Delivery. J Nanosci Nanotechnol, 2018. 18(8): 5207-5221.

[3]          Yan, B., Y. Wang, L. Wang, Y. Zhou, X. Shang, J. Zhao, Y. Liu, and J. Du, Design and synthesis of a novel multifunctional stabilizer for highly stable dl-tetrahydropalmatine nanosuspensions and in vitro study. Applied Nanoscience, 2018. 8(6): 1285-1297.

[4]          Wang, L., Y. Ma, Y. Gu, Y. Liu, J. Zhao, B. Yan, and Y. Wang, Cryoprotectant choice and analyses of freeze-drying drug suspension of nanoparticles with functional stabilisers. J Microencapsul, 2018. 35(3): 241-248.

[5]          Liu, Y., J. Zhao, L. Wang, B. Yan, Y. Gu, P. Chang, and Y. Wang, Nanocrystals Technology for Transdermal Delivery of Water-Insoluble Drugs. Curr Drug Deliv, 2018. 15(9): 1221-1229.

[6]          Liu, Y., Y. Wang, and J. Zhao, Design, optimization and in vitro-in vivo evaluation of smart nanocaged carrier delivery of multifunctional PEG-chitosan stabilized silybin nanocrystals. Int J Biol Macromol, 2018. 124: 667-680.

[7]          Du, J., Y. Zhou, L. Wang, J. Zhao, Y. Liu, C. Li, and Y. Wang, Deacetyl Mycoepoxydience Nanocrystals Dispersible Tablets Formulation and In Vitro Study. J Nanosci Nanotechnol, 2018. 18(6): 3850-3855.

[8]          Zhou, Y., J. Du, L. Wang, and Y. Wang, Nanocrystals Technology for Improving Bioavailability of Poorly Soluble Drugs: A Mini-Review. Journal of Nanoscience and Nanotechnology, 2017. 17(1): 18-28.

[9]          Wang, L., Y. Liu, J. Zhao, C. Li, Y. Zhou, J. Du, and Y. Wang, In vitro and in vivo evaluation of targeting tumor with folate-based amphiphilic multifunctional stabilizer for resveratrol nanosuspensions. Colloids Surf B Biointerfaces, 2017. 160: 462-472.

[10]        Wang, L., J. Du, Y. Zhou, and Y. Wang, Safety of nanosuspensions in drug delivery. Nanomedicine, 2017. 13(2): 455-469.

[11]        Zhou, Y., J. Du, L. Wang, and Y. Wang, State of the art of nanocrystals technology for delivery of poorly soluble drugs. Journal of Nanoparticle Research, 2016. 18(9).

[12]        Du, J., Y. Zhou, L. Wang, and Y. Wang, Effect of PEGylated chitosan as multifunctional stabilizer for deacetyl mycoepoxydience nanosuspension design and stability evaluation. Carbohydr Polym, 2016. 153: 471-481.

[13]        Wang, Y., J. Song, S.F. Chow, A.H. Chow, and Y. Zheng, Particle size tailoring of ursolic acid nanosuspensions for improved anticancer activity by controlled antisolvent precipitation. Int J Pharm, 2015. 494(1): 479-89.

[14]        Du, J., X. Li, H. Zhao, Y. Zhou, L. Wang, S. Tian, and Y. Wang, Nanosuspensions of poorly water-soluble drugs prepared by bottom-up technologies. Int J Pharm, 2015. 495(2): 738-49.

[15]        Yancai Wang, X.M., Lin Suna, Ju Songa, Chao Bia, Xiao Yanga and Ying Zheng, Effects of Nanosuspension Formulations on Transport, Pharmacokinetics, In Vivo Targeting and Efficacy for Poorly Water-soluble Drugs. Current Pharmaceutical Design,, 2014.

[16]        Wang, Y., L. Zhang, Q. Wang, and D. Zhang, Recent Advances in the Nanotechnology-Based Drug Delivery of Silybin. Journal of Biomedical Nanotechnology, 2014. 10(4): 543-558.

[17]        Wang, Y., Y. Zheng, L. Zhang, Q. Wang, and D. Zhang, Stability of nanosuspensions in drug delivery. J Control Release, 2013. 172(3): 1126-41.   ESI高被引论文

[18]        Wang, Y., Y. Ma, Y. Zheng, J. Song, X. Yang, C. Bi, D. Zhang, and Q. Zhang, In vitro and in vivo anticancer activity of a novel puerarin nanosuspension against colon cancer, with high efficacy and low toxicity. Int J Pharm, 2013. 441(1-2): 728-35.

[19]        Wang, Y., L. Wang, Z. Liu, D. Zhang, and Q. Zhang, In Vivo Evaluation Evaluation of Silybin Nanosuspensions Targeting Liver. Journal of Biomedical Nanotechnology, 2012. 8(5): 760-769.

[20]        Wang, Y., Y. Ma, Y. Ma, Y. Du, Z. Liu, D. Zhang, and Q. Zhang, Formulation and Pharmacokinetics Evaluation of Puerarin Nanocrystals for Intravenous Delivery. Journal of Nanoscience and Nanotechnology, 2012. 12(8): 6176-6184.

[21]       Wang, Y., Z. Liu, D. Zhang, X. Gao, X. Zhang, C. Duan, L. Jia, F. Feng, Y. Huang, Y. Shen, and Q. Zhang, Development and in vitro evaluation of deacety mycoepoxydiene nanosuspension. Colloids Surf B Biointerfaces, 2011. 83(2): 189-97.

[22]        Wang, Y., D. Zhang, Z. Liu, G. Liu, C. Duan, L. Jia, F. Feng, X. Zhang, Y. Shi, and Q. Zhang, In vitro and in vivo evaluation of silybin nanosuspensions for oral and intravenous delivery. Nanotechnology, 2010. 21(15): 155104.


 


科研及荣誉:

2018届 2017届 学院毕业生最感恩教师

2017年山东省高等学校科学技术一等奖

2017年中央本级重大增减支项目

2014年山东省高等学校优秀科研成果三等奖

2013年国家自然科学基金青年基金

2013年齐鲁工业大学  先进个人  优秀教师 

2012年山东省优秀中青年科学家科研奖励基金

 

研究方向:
1.纳米结晶速释及缓控释制剂开发:依托纳米技术,解决新药开发中药物制剂学相关难题,特别是通过纳米结晶技术,实现难溶性候选化合物的制剂开发。目前,已经完成水飞蓟宾、葛根素等多个品种的药学研究、稳定性试验和初步的安全性评价,并获得黄豆苷元纳米结晶速释胶囊等多项专利技术。

2.新型缓控释中药制剂开发:主要是采用缓控释微丸技术,针对当前中药有效部位进行开发,实现中药药剂的时辰药理学给药和靶部位释药,实现释放时间和释药部位的控制。

 

 

 


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